Retinoblastoma Protein (Rb) Antikörper (AA 586-615)

Produktnummer ABIN3032465

Der Kaninchen Polyklonal Anti-Retinoblastoma Protein (Rb)-Antikörper wurde für WB, ELISA, IHC und IF validiert. Er ist geeignet, Retinoblastoma Protein (Rb) in Proben von Human zu detektieren.

Kurzübersicht für Retinoblastoma Protein (Rb) Antikörper (AA 586-615) (ABIN3032465)

Target: Retinoblastoma Protein (Rb) (Rb Protein) (Retinoblastoma Protein (Rb Protein))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Retinoblastoma Protein (Rb) Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-Retinoblastoma Protein (Rb) Antikörper

Bindungsspezifität: AA 586-615

Aufreinigung: Antigen affinity purified

Immunogen: A portion of amino acids 586-615 from the human protein was used as the immunogen for this Rb antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Titration of the Rb antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,Immunofluorescence: 1:10-1:50,IHC (Paraffin): 1:10-1:50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the Rb antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu Retinoblastoma Protein (Rb)

Target: Retinoblastoma Protein (Rb) (Rb Protein) (Retinoblastoma Protein (Rb Protein))

Andere Bezeichnung: Rb (Retinoblastoma)

Hintergrund: The retinoblastoma protein is a tumor suppressor protein that is dysfunctional in many types of cancer. One highly studied function of pRb is to prevent excessive cell growth by inhibiting cell cycle progression until a cell is ready to divide. pRb belongs to the pocket protein family, whose members have a pocket for the functional binding of other proteins. Should an oncogenic protein, such as those produced by cells infected by high-risk types of human papillomaviruses, bind and inactivate pRb, this can lead to cancer. Retinoblastoma (Rb) is an embryonic malignant neoplasm of retinal origin. It almost always presents in early childhood and is often bilateral.

UniProt: P06400

Pathways: Mitotic G1-G1/S Phases