PROX1 Antikörper (AA 492-522)

Produktnummer ABIN3032348

Der Kaninchen Polyklonal Anti-PROX1-Antikörper wurde für WB, ELISA und IF validiert. Er ist geeignet, PROX1 in Proben von Human und Ratte zu detektieren.

Kurzübersicht für PROX1 Antikörper (AA 492-522) (ABIN3032348)

Target: PROX1 (Prospero Homeobox 1 (PROX1))

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PROX1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Produktdetails anti-PROX1 Antikörper

Bindungsspezifität: AA 492-522

Kreuzreaktivität (Details): Expected species reactivity: Mouse

Aufreinigung: Purified

Immunogen: A portion of amino acids 492-522 from the human protein was used as the immunogen for this PROX1 antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Titration of the PROX1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:500,Immunofluorescence: 1:10-1:50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the PROX1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu PROX1

Target: PROX1 (Prospero Homeobox 1 (PROX1))

Andere Bezeichnung: PROX1

Hintergrund: The expression pattern of Prox1 suggests that it has a role in a variety of embryonic tissues, including lens. Prox mRNA is present in many different human tissues with lens demonstrating the highest level. Homozygous Prox1-null mice die at midgestation from multiple developmental defects, and a targeted effect on lens development has been reported. Prox1 inactivation caused abnormal cellular proliferation, downregulated expression of the cell cycle inhibitors Cdkn1b and Cdkn1c, misexpression of E-cadherin, and excessive apoptosis. Consequently, mutant lens cells failed to polarize and elongate properly, resulting in a hollow lens.

UniProt: Q92786

Pathways: Stem Cell Maintenance, Regulation of Muscle Cell Differentiation