This phospho-TSC1 antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pS312 of rat TSC1.
TSC1
Reaktivität: Human, Maus, Schaf
ELISA, WB, IF (cc), IF (p), IHC (p), IHC (fro)
Wirt: Kaninchen
Polyclonal
unconjugated
Applikationshinweise
Titration of the phospho-TSC1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Dot blot: 1:500
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Buffer
In 1X PBS, pH 7.4, with 0.09 % sodium azide
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
-20 °C
Informationen zur Lagerung
Aliquot the phospho-TSC1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Target
TSC1
(Tuberous Sclerosis 1 (TSC1))
Andere Bezeichnung
TSC1
Hintergrund
In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (By similarity). Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling (By similarity).