FAS Antikörper (pTyr291)
Kurzübersicht für FAS Antikörper (pTyr291) (ABIN3030905)
Target
Alle FAS Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- pTyr291
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Verwendungszweck
- Phospho-Fas Antibody (pY291)
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Aufreinigung
- Antigen affinity
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Immunogen
- This phospho-Fas antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pY291 of human Fas.
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Isotyp
- Ig Fraction
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Applikationshinweise
- Titration of the phospho-Fas antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Buffer
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- Aliquot the phospho-Fas antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- FAS (TNF Receptor Superfamily, Member 6 (FAS))
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Andere Bezeichnung
- Fas
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Hintergrund
- Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Fas-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). [UniProt]
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UniProt
- P25445
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Pathways
- p53 Signalweg, Apoptose, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity
Target
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