ErbB2/Her2 Antikörper (pTyr1127)

Produktnummer ABIN3029500

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch ErbB2/Her2 in WB, ELISA, IF und DB. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für ErbB2/Her2 Antikörper (pTyr1127) (ABIN3029500)

Target: ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ErbB2/Her2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Dot Blot (DB)

Produktdetails anti-ErbB2/Her2 Antikörper

Bindungsspezifität: pTyr1127

Aufreinigung: Antigen affinity purified

Immunogen: This phos-ERBB2 antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pY1127 of human HER2/ERBB2.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Titration of the phos-ERBB2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000-5000,Immunofluorescence: 1:100,Dot blot: 1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the phos-ERBB2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu ErbB2/Her2

Target: ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))

Andere Bezeichnung: Erbb2

Hintergrund: This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.

UniProt: P04626

Pathways: RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Skeletal Muscle Fiber Development