PHF1 Antikörper (N-Term)
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- Target Alle PHF1 Antikörper anzeigen
- PHF1 (PHD Finger Protein 1 (PHF1))
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Bindungsspezifität
- N-Term
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Reaktivität
- Maus
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser PHF1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA
- Aufreinigung
- Antigen affinity purified
- Immunogen
- This PHF1 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 164-197 amino acids from the N-terminal region of human PHF1.
- Isotyp
- Ig Fraction
- Top Product
- Discover our top product PHF1 Primärantikörper
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anti-PHD Finger Protein 1 (PHF1) (AA 2-100) antibody
PHF1 Reaktivität: Human WB, ELISA, IF Wirt: Maus Monoclonal 2G7 unconjugated
anti-PHD Finger Protein 1 (PHF1) (AA 151-360) antibodyPHF1 Reaktivität: Human WB, ELISA, IHC, IF Wirt: Kaninchen Polyclonal unconjugated
anti-PHD Finger Protein 1 (PHF1) (AA 2-100) antibodyPHF1 Reaktivität: Human WB, ELISA Wirt: Maus Monoclonal 4F5 unconjugated
anti-PHD Finger Protein 1 (PHF1) (AA 2-100) antibodyPHF1 Reaktivität: Human WB, ELISA Wirt: Maus Monoclonal 2D3 unconjugated
anti-PHD Finger Protein 1 (PHF1) (AA 1-567) antibodyPHF1 Reaktivität: Human WB Wirt: Kaninchen Polyclonal unconjugated
anti-PHD Finger Protein 1 (PHF1) (Internal Region) antibodyPHF1 Reaktivität: Human, Maus, Ratte WB, ELISA, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-PHD Finger Protein 1 (PHF1) (AA 421-470) antibodyPHF1 Reaktivität: Human, Ratte, Hund, Kaninchen, Meerschweinchen, Fledermaus, Schwein WB, IHC Wirt: Kaninchen Polyclonal unconjugated
anti-PHD Finger Protein 1 (PHF1) (Internal Region) antibodyPHF1 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC Wirt: Kaninchen Polyclonal unconjugated
anti-PHD Finger Protein 1 (PHF1) (AA 164-197), (N-Term) antibodyPHF1 Reaktivität: Maus WB Wirt: Kaninchen Polyclonal RB48341 unconjugated
anti-PHD Finger Protein 1 (PHF1) (AA 2-100) antibodyPHF1 Reaktivität: Human WB, ELISA Wirt: Maus Polyclonal unconjugated
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- Applikationshinweise
- Titration of the PHF1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Aliquot the PHF1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- Target
- PHF1 (PHD Finger Protein 1 (PHF1))
- Andere Bezeichnung
- PHF1 (PHF1 Produkte)
- Hintergrund
- Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Involved in DNA damage response and is recruited at double-strand breaks (DSBs). Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex: it is however unclear whether recruitment of the PRC2 complex to H3K36me3 leads to enhance or inhibit H3K27me3 methylation mediated by the PRC2 complex. According to some reports, PRC2 recruitment by PHF1 promotes H3K27me3 and subsequent gene silencing by inducing spreading of PRC2 and H3K27me3 into H3K36me3 loci (PubMed:18285464 and PubMed:23273982). According to another report, PHF1 recruits the PRC2 complex at double-strand breaks (DSBs) and inhibits the activity of PRC2 (PubMed:23142980). Regulates p53/TP53 stability and prolonges its turnover: may act by specifically binding to a methylated from of p53/TP53.
- UniProt
- O43189
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