PHF1 Antikörper (N-Term)

Produktnummer ABIN6242526

Produktdetails anti-PHF1 Antikörper

Target: PHF1 (PHD Finger Protein 1 (PHF1))

Bindungsspezifität: AA 164-197, N-Term

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PHF1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This PHF1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 164-197 amino acids from the N-terminal region of human PHF1.

Klon: RB48341

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu PHF1

Target: PHF1 (PHD Finger Protein 1 (PHF1))

Andere Bezeichnung: PHF1 (PHF1 Produkte)

Synonyme: pcl1 antikoerper, xpcl1 antikoerper, MTF2L2 antikoerper, PCL1 antikoerper, PHF2 antikoerper, TDRD19C antikoerper, hPHF1 antikoerper, AW557215 antikoerper, D17Ertd455e antikoerper, Tctex-3 antikoerper, Tctex3 antikoerper, mPcl1 antikoerper, PHD finger protein 1 L homeolog antikoerper, PHD finger protein 1 antikoerper, phf1.L antikoerper, PHF1 antikoerper, Phf1 antikoerper

Hintergrund: Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Involved in DNA damage response and is recruited at double-strand breaks (DSBs). Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex: it is however unclear whether recruitment of the PRC2 complex to H3K36me3 leads to enhance or inhibit H3K27me3 methylation mediated by the PRC2 complex. According to some reports, PRC2 recruitment by PHF1 promotes H3K27me3 and subsequent gene silencing by inducing spreading of PRC2 and H3K27me3 into H3K36me3 loci (PubMed:18285464 and PubMed:23273982). According to another report, PHF1 recruits the PRC2 complex at double-strand breaks (DSBs) and inhibits the activity of PRC2 (PubMed:23142980). Regulates p53/TP53 stability and prolonges its turnover: may act by specifically binding to a methylated from of p53/TP53.

Molekulargewicht: 62106

UniProt: O43189