P-Glycoprotein Antikörper (AA 647-677)

Produktnummer ABIN3032111

Der Kaninchen Polyklonal anti-P-Glycoprotein Antikörper wird verwendet zum Nachweis von P-Glycoprotein in Proben von Human. Er wurde validiert für WB und ELISA.

Kurzübersicht für P-Glycoprotein Antikörper (AA 647-677) (ABIN3032111)

Target: P-Glycoprotein

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser P-Glycoprotein Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-P-Glycoprotein Antikörper

Bindungsspezifität: AA 647-677

Verwendungszweck: P-Glycoprotein Antibody

Aufreinigung: Purified

Immunogen: A portion of amino acids 647-677 from the human protein was used as the immunogen for this P-Glycoprotein antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Titration of the P-Glycoprotein antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the P-Glycoprotein antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu P-Glycoprotein

Target: P-Glycoprotein

Hintergrund: The membrane-associated ABCB1 protein is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. ABCB1 is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.

UniProt: P08183