MELK Antikörper (AA 381-415)

Produktnummer ABIN3031706

Der Kaninchen Polyklonal Anti-MELK-Antikörper wurde für WB und ELISA validiert. Er ist geeignet, MELK in Proben von Maus zu detektieren.

Kurzübersicht für MELK Antikörper (AA 381-415) (ABIN3031706)

Target: MELK (Maternal Embryonic Leucine Zipper Kinase (MELK))

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MELK Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-MELK Antikörper

Bindungsspezifität: AA 381-415

Aufreinigung: Antigen affinity purified

Immunogen: This mouse Melk antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 381-415 amino acids from the Central region of mouse Melk.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Titration of the Melk antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the Melk antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu MELK

Target: MELK (Maternal Embryonic Leucine Zipper Kinase (MELK))

Andere Bezeichnung: Melk

Hintergrund: Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity, phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis.

UniProt: Q61846