Lamin A/C Antikörper (AA 465-498)

Produktnummer ABIN3031584

Dieses Anti-Lamin A/C-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Lamin A/C in WB und ELISA. Geeignet für Human.

Kurzübersicht für Lamin A/C Antikörper (AA 465-498) (ABIN3031584)

Target: Lamin A/C (LMNA)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Lamin A/C Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-Lamin A/C Antikörper

Bindungsspezifität: AA 465-498

Aufreinigung: Antigen affinity purified

Immunogen: This Lamin A/C antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 465-498 amino acids from the Central region of the human protein.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Titration of the Lamin A/C antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:500-1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the Lamin A/C antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu Lamin A/C

Target: Lamin A/C (LMNA)

Andere Bezeichnung: Lamin A/C

Hintergrund: Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation. Required for osteoblastogenesis and bone formation. Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone.

UniProt: P02545

Pathways: Apoptose, Caspase Kaskade in der Apoptose, ER-Nucleus Signaling, Protein targeting to Nucleus