JMJD2D Antikörper (AA 484-516)

Produktnummer ABIN3031654

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch JMJD2D in ELISA und WB. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für JMJD2D Antikörper (AA 484-516) (ABIN3031654)

Target: JMJD2D (KDM4D) (Lysine (K)-Specific Demethylase 4D (KDM4D))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser JMJD2D Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB)

Produktdetails anti-JMJD2D Antikörper

Bindungsspezifität: AA 484-516

Aufreinigung: Purified

Immunogen: A portion of amino acids 484-516 from the human protein was used as the immunogen for this JMJD2D antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Titration of the JMJD2D antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS pH 7.4 with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the JMJD2D antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu JMJD2D

Target: JMJD2D (KDM4D) (Lysine (K)-Specific Demethylase 4D (KDM4D))

Andere Bezeichnung: JMJD2D (KDM4D)

Hintergrund: Covalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9). Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed.

UniProt: Q6B0I6

Pathways: Warburg Effekt