ILK Antikörper (AA 391-421)

Produktnummer ABIN3031391

Produktdetails anti-ILK Antikörper

Target: ILK (Integrin-Linked Kinase (ILK))

Bindungsspezifität: AA 391-421

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ILK Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Kreuzreaktivität (Details): Expected species reactivity: Rat, Bovine

Aufreinigung: Purified

Immunogen: A portion of amino acids 391-421 from the human protein was used as the immunogen for this ILK2/ILK1 antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Titration of the ILK2/ILK1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS pH 7.4 with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the ILK2/ILK1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu ILK

Target: ILK (Integrin-Linked Kinase (ILK))

Andere Bezeichnung: ILK2/ILK1 (ILK Produkte)

Synonyme: CG10504 antikoerper, CT29478 antikoerper, DmILK antikoerper, Dmel\\CG10504 antikoerper, ILK antikoerper, ilk antikoerper, l(3)78Ca antikoerper, p59 antikoerper, AA511515 antikoerper, ESTM24 antikoerper, zgc:65842 antikoerper, ILK-1 antikoerper, ILK-2 antikoerper, P59 antikoerper, p59ILK antikoerper, Integrin linked kinase antikoerper, integrin linked kinase antikoerper, integrin linked kinase S homeolog antikoerper, integrin-linked protein kinase antikoerper, integrin-linked kinase antikoerper, Ilk antikoerper, ILK antikoerper, ilk.S antikoerper, CpipJ_CPIJ016644 antikoerper, Bm1_20815 antikoerper, Tsp_07213 antikoerper, Tsp_07224 antikoerper, Tsp_15354 antikoerper, ilk antikoerper

Hintergrund: Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK) is an ankyrin repeat containing 51 kDa receptor-proximate serine-threonine kinase (1), with a reported migration rate of 59K. This 451 amino acid protein interacts with the cytoplasmic domain of the beta-1 integrin subunit and contains sequence motifs found in pleckstrin homology domains capable of interacting with phosphoinositide lipids. ILK is an upstream regulator of Pi(3)K dependant activation of protein kinase B (PKB/AKT) and inhibition of glycogen synthase kinase 3 (GSK-3). ILK2 expression is associated with mediation of cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. ILK2 is overexpressed in some highly invasive tumor cell lines.

UniProt: Q13418

Pathways: Regulation of Muscle Cell Differentiation, Regulation of Cell Size, Maintenance of Protein Location, Skeletal Muscle Fiber Development, Smooth Muscle Cell Migration