IL12B Antikörper (AA 264-290)

Produktnummer ABIN3031446

Dieses Anti-IL12B-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von IL12B in WB, ELISA, IHC und FACS. Geeignet für Human.

Kurzübersicht für IL12B Antikörper (AA 264-290) (ABIN3031446)

Target: IL12B (Interleukin 12 beta (IL12B))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IL12B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)

Produktdetails anti-IL12B Antikörper

Bindungsspezifität: AA 264-290

Aufreinigung: Antigen affinity purified

Immunogen: A portion of amino acids 264-290 from the human protein was used as the immunogen for this IL-12B antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Titration of the IL-12B antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. IHC (Paraffin): 1:50-1:100,Flow Cytometry: 1:10-1:50,Western blot: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the IL-12B antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu IL12B

Target: IL12B (Interleukin 12 beta (IL12B))

Andere Bezeichnung: IL-12B

Hintergrund: IL12B is a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children.

UniProt: P29460

Pathways: JAK-STAT Signalweg, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation