HES1 Antikörper (C-Term)

Produktnummer ABIN3031193

Der Kaninchen Polyklonal Anti-HES1-Antikörper wurde für WB und ELISA validiert. Er ist geeignet, HES1 in Proben von Human zu detektieren.

Kurzübersicht für HES1 Antikörper (C-Term) (ABIN3031193)

Target: HES1 (Hes Family bHLH Transcription Factor 1 (HES1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HES1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-HES1 Antikörper

Bindungsspezifität: C-Term

Kreuzreaktivität (Details): Expected species reactivity: Bovine

Aufreinigung: Antigen affinity purified

Immunogen: This HES1 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 259-293 amino acids from the C-terminal region of human HES1.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Titration of the HES1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the HES1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu HES1

Target: HES1 (Hes Family bHLH Transcription Factor 1 (HES1))

Andere Bezeichnung: HES1

Hintergrund: Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage.

UniProt: Q14469

Pathways: DNA Reparatur