HES1 Antikörper (AA 102-137)

Produktnummer ABIN3031192

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch HES1 in WB und ELISA. Er zeigt eine Reaktivität gegenüber Maus.

Kurzübersicht für HES1 Antikörper (AA 102-137) (ABIN3031192)

Target: HES1 (Hes Family bHLH Transcription Factor 1 (HES1))

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HES1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-HES1 Antikörper

Bindungsspezifität: AA 102-137

Kreuzreaktivität (Details): Expected species reactivity: Bovine, Human, Rat, Xenopus

Aufreinigung: Antigen affinity purified

Immunogen: This mouse Hes1 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 102-137 amino acids from the Central region of mouse Hes1.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Titration of the Hes1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the Hes1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu HES1

Target: HES1 (Hes Family bHLH Transcription Factor 1 (HES1))

Andere Bezeichnung: Hes1

Hintergrund: Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1 (By similarity). Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity. May play a role in a functional FA core complex response to DNA cross- link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage (By similarity).

UniProt: P35428

Pathways: DNA Reparatur