HDAC6 Antikörper (AA 1182-1215)

Produktnummer ABIN3031235

Der Kaninchen Polyklonal Anti-HDAC6-Antikörper wurde für WB, IHC und ELISA validiert. Er ist geeignet, HDAC6 in Proben von Human und Maus zu detektieren.

Kurzübersicht für HDAC6 Antikörper (AA 1182-1215) (ABIN3031235)

Target: HDAC6 (Histone Deacetylase 6 (HDAC6))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HDAC6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Produktdetails anti-HDAC6 Antikörper

Bindungsspezifität: AA 1182-1215

Aufreinigung: Purified

Immunogen: A portion of amino acids 1182-1215 from the human protein was used as the immunogen for this HDAC6 antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Titration of the HDAC6 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. IHC (Paraffin): 1:10-1:50,Western blot: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the HDAC6 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu HDAC6

Target: HDAC6 (Histone Deacetylase 6 (HDAC6))

Andere Bezeichnung: HDAC6

Hintergrund: HDAC6 (histone deacetylase 6) is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. HDAC6 plays a central role in microtubule-dependent cell motility via deacetylation of tubulin, and has been shown to interact with HDAC11, SIRT2, and F-actin. HDAC6 is ubiquitinated, but its polyubiquitination however does not lead to degradation. HDAC is also a potential target of sumoylation.

UniProt: Q9UBN7

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling