Glypican 3 Antikörper (AA 529-560)

Produktnummer ABIN3031100

Der Kaninchen Polyklonal Anti-Glypican 3-Antikörper wurde für IF, WB und ELISA validiert. Er ist geeignet, Glypican 3 in Proben von Human und Maus zu detektieren.

Kurzübersicht für Glypican 3 Antikörper (AA 529-560) (ABIN3031100)

Target: Glypican 3 (GPC3)

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Glypican 3 Antikörper ist unkonjugiert

Applikation: Immunofluorescence (IF), Western Blotting (WB), ELISA

Produktdetails anti-Glypican 3 Antikörper

Bindungsspezifität: AA 529-560

Aufreinigung: Purified

Immunogen: A portion of amino acids 529-560 from the human protein was used as the immunogen for this GPC3 antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Titration of the GPC3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Immunofluorescence: 1:10-1:50,Western blot: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the GPC3 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu Glypican 3

Target: Glypican 3 (GPC3)

Andere Bezeichnung: GPC3

Hintergrund: GPC3 is a cell surface proteoglycan that bears heparan sulfate. This protein may be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs, and may play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function. Members of the glypican-related integral membrane proteoglycan family contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol (GPI) linkage. These proteins may play a role in the control of cell division, growth regulation, and tumor predisposition. Deletion mutations in GPC3 are the cause of Simpson-Golabi-Behmel syndrome (SGBS), also known as Simpson dysmorphia syndrome (SDYS). SGBS is a condition characterized by pre- and postnatal overgrowth (gigantism) with visceral and skeletal anomalies.

UniProt: P51654

Pathways: Glycosaminoglycan Metabolic Process