Glypican 3 Antikörper (AA 21-50)

Produktnummer ABIN3031098

Dieses Anti-Glypican 3-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Glypican 3 in WB, IHC und ELISA. Geeignet für Human und Maus.

Kurzübersicht für Glypican 3 Antikörper (AA 21-50) (ABIN3031098)

Target: Glypican 3 (GPC3)

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Glypican 3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Produktdetails anti-Glypican 3 Antikörper

Bindungsspezifität: AA 21-50

Aufreinigung: Purified

Immunogen: A portion of amino acids 21-50 from the human protein was used as the immunogen for this Glypican 3 antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Titration of the Glypican 3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the Glypican 3 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu Glypican 3

Target: Glypican 3 (GPC3)

Andere Bezeichnung: Glypican 3

Hintergrund: GPC3 is a cell surface proteoglycan that bears heparan sulfate. This protein may be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs, and may play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function. Members of the glypican-related integral membrane proteoglycan family contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol (GPI) linkage. These proteins may play a role in the control of cell division, growth regulation, and tumor predisposition. Deletion mutations in GPC3 are the cause of Simpson-Golabi-Behmel syndrome (SGBS), also known as Simpson dysmorphia syndrome (SDYS). SGBS is a condition characterized by pre- and postnatal overgrowth (gigantism) with visceral and skeletal anomalies.

UniProt: P51654

Pathways: Glycosaminoglycan Metabolic Process