EPH Receptor A2 Antikörper (AA 518-552)

Produktnummer ABIN3030815

Der Kaninchen Polyklonal Anti-EPH Receptor A2-Antikörper wurde für WB und ELISA validiert. Er ist geeignet, EPH Receptor A2 in Proben von Human zu detektieren.

Kurzübersicht für EPH Receptor A2 Antikörper (AA 518-552) (ABIN3030815)

Target: EPH Receptor A2 (EPHA2)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EPH Receptor A2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-EPH Receptor A2 Antikörper

Bindungsspezifität: AA 518-552

Kreuzreaktivität (Details): Expected species reactivity: Primate

Aufreinigung: Antigen affinity purified

Immunogen: This EPHA2 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 518-552 amino acids from the central region of human EPHA2.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Titration of the EPHA2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the EPHA2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu EPH Receptor A2

Target: EPH Receptor A2 (EPHA2)

Andere Bezeichnung: EPHA2

Hintergrund: Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand- independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.

UniProt: P29317

Pathways: RTK Signalweg