EPH Receptor A2 Antikörper (AA 296-323)

Produktnummer ABIN3030814

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch EPH Receptor A2 in WB und ELISA. Er zeigt eine Reaktivität gegenüber Maus.

Kurzübersicht für EPH Receptor A2 Antikörper (AA 296-323) (ABIN3030814)

Target: EPH Receptor A2 (EPHA2)

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EPH Receptor A2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-EPH Receptor A2 Antikörper

Bindungsspezifität: AA 296-323

Aufreinigung: Antigen affinity purified

Immunogen: A portion of amino acids 296-323 from the mouse protein was used as the immunogen for this Epha2 antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Titration of the Epha2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the Epha2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu EPH Receptor A2

Target: EPH Receptor A2 (EPHA2)

Andere Bezeichnung: Epha2

Hintergrund: Receptor for members of the ephrin-A family. Binds to ephrin-A1, -A3, -A4 and -A5. Induces apoptosis in a TP53/p53-independent, caspase-8-dependent manner (By similarity). Plays an important role in angiogenesis and tumor neovascularization. The recruitement of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. May function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. May be involved in cell-cell interactions guiding early hindbrain development.

UniProt: Q03145

Pathways: RTK Signalweg