CXCR3 Antikörper (AA 140-167)

Produktnummer ABIN3030510

Produktdetails anti-CXCR3 Antikörper

Target: CXCR3 (Chemokine (C-X-C Motif) Receptor 3 (CXCR3))

Bindungsspezifität: AA 140-167

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CXCR3 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Aufreinigung: Antigen affinity purified

Immunogen: A portion of amino acids 140-167 from the human protein was used as the immunogen for this CXCR3 antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Titration of the CXCR3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100,Flow Cytometry: 1:10-1:50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the CXCR3 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu CXCR3

Target: CXCR3 (Chemokine (C-X-C Motif) Receptor 3 (CXCR3))

Andere Bezeichnung: CXCR3 (CXCR3 Produkte)

Synonyme: CD182 antikoerper, CD183 antikoerper, CKR-L2 antikoerper, CMKAR3 antikoerper, GPR9 antikoerper, IP10-R antikoerper, Mig-R antikoerper, MigR antikoerper, Cd183 antikoerper, Cmkar3 antikoerper, CXCR3 antikoerper, cxcr3 antikoerper, Gpr9 antikoerper, CXC-R3 antikoerper, CXCR-3 antikoerper, zgc:92301 antikoerper, sb:eu378 antikoerper, C-X-C motif chemokine receptor 3 antikoerper, chemokine (C-X-C motif) receptor 3 antikoerper, chemokine (C-X-C motif) receptor 3, tandem duplicate 2 antikoerper, chemokine (C-X-C motif) receptor 3, tandem duplicate 1 antikoerper, CXCR3 antikoerper, Cxcr3 antikoerper, cxcr3 antikoerper, cxcr3.2 antikoerper, cxcr3.1 antikoerper

Hintergrund: This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed IP10 (interferon-g-inducible 10 kDa protein), Mig (monokine induced by interferon-g) and I-TAC (interferon-inducible T cell a-chemoattractant). IP10, Mig and I-TAC belong to the structural subfamily of CXC chemokines, in which a single amino acid residue separates the first two of four highly conserved Cys residues. Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Inhibition by Bordetella pertussis toxin suggests that heterotrimeric G protein of the Gi-subclass couple to this protein. Signal transduction has not been further analyzed but may include the same enzymes that were identified in the signaling cascade induced by other chemokine receptors. As a consequence of chemokine-induced cellular desensitization (phosphorylation-dependent receptor internalization), cellular responses are typically rapid and short in duration. Cellular responsiveness is restored after dephosphorylation of intracellular receptors and subsequent recycling to the cell surface. This gene is prominently expressed in in vitro cultured effector/memory T cells, and in T cells present in many types of inflamed tissues. In addition, IP10, Mig and I-TAC are commonly produced by local cells in inflammatory lesion, suggesting that this gene and its chemokines participate in the recruitment of inflammatory cells. Therefore, this protein is a target for the development of small molecular weight antagonists, which may be used in the treatment of diverse inflammatory diseases. Multiple transcript variants encoding different isoforms have been found for this gene.

UniProt: P49682