FAS Antikörper

Produktnummer ABIN4953250

Der Maus Monoklonal Anti-FAS-Antikörper wurde für WB validiert. Er ist geeignet, FAS in Proben von Human und Ratte zu detektieren.

Kurzübersicht für FAS Antikörper (ABIN4953250)

Target: FAS (TNF Receptor Superfamily, Member 6 (FAS))

Reaktivität: Human, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser FAS Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: 8C1-B9-F12

Produktdetails anti-FAS Antikörper

Aufreinigung: Protein G affinity

Immunogen: A human recombinant protein was used as the immunogen for this Fas antibody.

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting points. Titration of the Fas antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Antibody in PBS with 50 % Glycerol and 0.03 % ProClin 300

Lagerung: -20 °C

Informationen zur Lagerung: Store the Fas antibody at -20°C.

Details zu FAS

Target: FAS (TNF Receptor Superfamily, Member 6 (FAS))

Andere Bezeichnung: Fas / CD95

Hintergrund: Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). [UniProt]

UniProt: P25445

Pathways: p53 Signalweg, Apoptose, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity