Der Maus Monoklonal anti-Desmoglein 1 Antikörper wird verwendet zum Nachweis von Desmoglein 1 in Proben von Human. Er wurde validiert für WB, IF und FACS.
Verified
DSG1
Reaktivität: Human
IHC, ELISA
Wirt: Ziege
Polyclonal
unconjugated
Applikationshinweise
Optimal dilution of the DSG1 antibody should be determined by the researcher.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Konzentration
1 mg/mL
Buffer
1 mg/mL in 1X PBS, BSA free, sodium azide free
Konservierungsmittel
Azide free
Lagerung
4 °C,-20 °C
Informationen zur Lagerung
Store the DSG1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Target
Desmoglein 1 (DSG1)
Andere Bezeichnung
DSG1
Hintergrund
Desmoglein 1 (DSG1) is a member of the desmosomal cadherin family. Desmosomes are intercellular adhering junctions that represent cell surface attachment sites for intermediate filament. Desmocollins and desmogleins are the main desmosomal transmembrane proteins. Desmogleins consist of Dsg1, Dsg2, Dsg3, and Dsg4 isoforms. Within the desmosome, the extracellular domain of desmoglein is essential for calcium dependent heterophilic binding to the desmocollins, whereas the intracellular domain is essential for binding to the desmosomal plaque protein, plakoglobin. Desmoglein 1 is synthesized exclusively in the suprabasal layers. Intact and functionally active desmoglein 1 is essential to epidermal integrity.