Aurora Kinase B Antikörper (AA 89-251)

Produktnummer ABIN4949412

Dieses Maus Monoklonal-Antikörper erkennt spezifisch Aurora Kinase B in WB, IF und FACS. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für Aurora Kinase B Antikörper (AA 89-251) (ABIN4949412)

Target: Aurora Kinase B (AURKB)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Aurora Kinase B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)

Klon: AURKB-1521

Produktdetails anti-Aurora Kinase B Antikörper

Bindungsspezifität: AA 89-251

Aufreinigung: Protein G affinity

Immunogen: Amino acids 89-251 were used as the immunogen for this Aurora B antibody.

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Aurora B antibody should be determined by the researcher.\. Western blot: 0.5-1 μg/mL,FACS: 0.5-1 μg/10e6 cells in 0.1ml,IF: 1-2 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the Aurora B antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

Details zu Aurora Kinase B

Target: Aurora Kinase B (AURKB)

Andere Bezeichnung: Aurora B / AURKB

Hintergrund: Recognizes a protein of 39-45  kDa, which is identified as Aurora B. The serine/threonine protein kinase aurora B (Aurora B) is a chromosomal passenger protein critical for accurate chromosome segregation, cytokinesis, protein localization to the centromere and kinetochore, correct microtubule-kinetochore attachment, and regulation of the mitotic checkpoint. Aurora B forms a tight complex with inner centrosome protein and survivin. Inactivation of any of these proteins causes similar defects in chromosome segregation. A significant overexpression of Aurora B has been found in a variety of human tumors including non-small cell lung carcinoma, astrocytoma, seminoma and carcinomas of the colon, prostate, endometrium and thyroid. The expression level of Aurora B is associated with cell proliferation and prognosis in these tumors.

Pathways: T-Zell Rezeptor Signalweg, Zellzyklus, Maintenance of Protein Location, Hepatitis C, Toll-Like Receptors Cascades