SUMO2 Antikörper

Produktnummer ABIN4914410

Der Maus Monoklonal anti-SUMO2 Antikörper wird verwendet zum Nachweis von SUMO2 in Proben von Human und Ratte. Er wurde validiert für WB, IF und IF (cc).

Kurzübersicht für SUMO2 Antikörper (ABIN4914410)

Target: SUMO2 (Small Ubiquitin Related Modifier 2 (SUMO2))

Reaktivität: Human, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SUMO2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunofluorescence (Cultured Cells) (IF (cc))

Klon: 7A3

Produktdetails anti-SUMO2 Antikörper

Kreuzreaktivität: Human, Ratte

Aufreinigung: Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Immunogen: Purified His-tagged SUMO2 protein was used to produced this monoclonal antibody.

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IF(ICC) 1:50-200
IF()

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu SUMO2

Target: SUMO2 (Small Ubiquitin Related Modifier 2 (SUMO2))

Andere Bezeichnung: SUMO2

Hintergrund:

Synonyms: HSMT3, SMT3B, SUMO3, Smt3A, SMT3H2, Small ubiquitin-related modifier 2, SUMO-2, SMT3 homolog 2, SUMO-3, Sentrin-2, Ubiquitin-like protein SMT3B, SUMO2

Background: Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2, CBX4 or ZNF451 (PubMed:26524494). This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (PubMed:18408734, PubMed:18538659, PubMed:21965678, PubMed:9556629). Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744).

Gen-ID: 6613

UniProt: P61956

Pathways: Methionine Biosynthetic Process