Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

RPA2 Antikörper

Dieses Maus Monoklonal-Antikörper erkennt spezifisch RPA2 in WB und IHC (p). Er zeigt eine Reaktivität gegenüber Human.
Produktnummer ABIN4913599

Kurzübersicht für RPA2 Antikörper (ABIN4913599)

Target

Alle RPA2 Antikörper anzeigen
RPA2 (Replication Protein A2, 32kDa (RPA2))

Reaktivität

  • 104
  • 76
  • 43
  • 4
  • 4
  • 4
  • 3
  • 2
  • 2
  • 1
  • 1
Human

Wirt

  • 118
  • 18
  • 2
  • 1
Maus

Klonalität

  • 106
  • 33
Monoklonal

Konjugat

  • 82
  • 6
  • 6
  • 5
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
Dieser RPA2 Antikörper ist unkonjugiert

Applikation

  • 111
  • 45
  • 44
  • 31
  • 28
  • 26
  • 24
  • 22
  • 12
  • 10
  • 6
  • 5
  • 4
  • 3
  • 3
  • 3
  • 1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon

5C3
  • Kreuzreaktivität

    Human

    Aufreinigung

    Purified by Protein G.

    Immunogen

    This RFA2 antibody is generated from a mouse immunized with a recombinant protein of human RFA2.

    Isotyp

    IgG1
  • Applikationshinweise

    WB 1:300-5000
    IHC-P 1:200-400

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    0.5 μg/μL

    Buffer

    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C for 12 months.

    Haltbarkeit

    12 months
  • Target

    RPA2 (Replication Protein A2, 32kDa (RPA2))

    Andere Bezeichnung

    RFA2

    Hintergrund

    Synonyms: REPA2, RPA32, RP-A p32, RP-A p34, Replication protein A 32 kDa subunit, Replication factor A protein 2, RF-A protein 2, Replication protein A 34 kDa subunit, RPA2, RPA34

    Background: As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Plays also a role in base excision repair (BER) probably through interaction with UNG. Through RFWD3 may activate CHEK1 and play a role in replication checkpoint control. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance.

    Gen-ID

    6118

    UniProt

    P15927

    Pathways

    Telomere Maintenance, DNA Reparatur, Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA
Sie sind hier:
Chat with us!