MUSK Antikörper

Produktnummer ABIN4912113

Produktdetails anti-MUSK Antikörper

Target: MUSK (Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK))

Reaktivität: Maus, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MUSK Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Kreuzreaktivität: Maus, Ratte

Aufreinigung: Purified by Protein G.

Immunogen: This mouse Musk antibody is generated from a mouse immunized with recombinant protein from mouse Musk.

Klon: 6D1

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu MUSK

Target: MUSK (Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK))

Andere Bezeichnung: Musk (MUSK Produkte)

Synonyme: unp antikoerper, fj98e12 antikoerper, zgc:63467 antikoerper, wu:fj98e12 antikoerper, si:dz46m7.2 antikoerper, si:dz57f23.3 antikoerper, si:busm1-57f23.3 antikoerper, musk-A antikoerper, MuSK antikoerper, MUSK antikoerper, Mdk4 antikoerper, Mlk antikoerper, Nsk1 antikoerper, Nsk2 antikoerper, Nsk3 antikoerper, muscle antikoerper, muscle associated receptor tyrosine kinase antikoerper, muscle, skeletal, receptor tyrosine kinase antikoerper, muscle associated receptor tyrosine kinase S homeolog antikoerper, MUSK antikoerper, musk antikoerper, musk.S antikoerper, Musk antikoerper

Hintergrund:

Synonyms: Mlk, Mdk4, Nsk1, Nsk2, Nsk3, Muscle, skeletal receptor tyrosine-protein kinase, Muscle-specific tyrosine-protein kinase receptor, MuSK, Muscle-specific kinase receptor

Background: Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle. Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK. DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering. May positively regulate Rho family GTPases through FNTA. Mediates the phosphorylation of FNTA which promotes prenylation, recruitment to membranes and activation of RAC1 a regulator of the actin cytoskeleton and of gene expression. Other effectors of the MUSK signaling include DNAJA3 which functions downstream of MUSK. May also play a role within the central nervous system by mediating cholinergic responses, synaptic plasticity and memory formation.

Gen-ID: 18198

UniProt: Q61006

Pathways: RTK Signalweg, Regulation of Muscle Cell Differentiation, Synaptic Membrane, Regulation of Cell Size, Skeletal Muscle Fiber Development