FZR1 Antikörper

Produktnummer ABIN4909759

Dieses Maus Monoklonal-Antikörper erkennt spezifisch FZR1 in WB und IF. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für FZR1 Antikörper (ABIN4909759)

Target: FZR1 (Fizzy/cell Division Cycle 20 Related 1 (FZR1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser FZR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Klon: 1C7

Produktdetails anti-FZR1 Antikörper

Kreuzreaktivität: Human

Aufreinigung: Purified by Protein G.

Immunogen: This FZR antibody is generated from a mouse immunized with a recombinant protein between1-496 amino acids from human FZR.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IF()

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu FZR1

Target: FZR1 (Fizzy/cell Division Cycle 20 Related 1 (FZR1))

Andere Bezeichnung: FZR

Hintergrund:

Synonyms: FZR, CDH1, FZR2, HCDH, HCDH1, CDC20C, Fizzy-related protein homolog, CDC20-like protein 1, Cdh1/Hct1 homolog, FZR1, FYR, KIAA1242

Background: Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis.

Gen-ID: 51343

UniProt: Q9UM11

Pathways: DNA Replication, Synthesis of DNA