TOR1A Antikörper

Produktnummer ABIN4908959

Produktdetails anti-TOR1A Antikörper

Target: TOR1A (Torsin Family 1, Member A (Torsin A) (TOR1A))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TOR1A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Kreuzreaktivität: Human

Aufreinigung: Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.

Immunogen: Purified His-tagged DYT1 protein(Fragment) was used to produced this monoclonal antibody.

Klon: 3C3

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu TOR1A

Target: TOR1A (Torsin Family 1, Member A (Torsin A) (TOR1A))

Andere Bezeichnung: DYT1 (TOR1A Produkte)

Synonyme: Dyt1 antikoerper, DQ2 antikoerper, DYT1 antikoerper, torsinA antikoerper, torsin family 1, member A antikoerper, torsin family 1 member A antikoerper, torsin family 1, member A (torsin A) antikoerper, Tor1a antikoerper, TOR1A antikoerper

Hintergrund:

Synonyms: DQ2, DYT1, Torsin-1A, Dystonia 1 protein, Torsin ATPase-1A, Torsin family 1 member A, TOR1A, TA, TORA

Background: Protein with chaperone functions important for the control of protein folding, processing, stability and localization as well as for the reduction of misfolded protein aggregates. Involved in the regulation of synaptic vesicle recycling, controls STON2 protein stability in collaboration with the COP9 signalosome complex (CSN). In the nucleus, may link the cytoskeleton with the nuclear envelope, this mechanism seems to be crucial for the control of nuclear polarity, cell movement and, specifically in neurons, nuclear envelope integrity. Participates in the cellular trafficking and may regulate the subcellular location of multipass membrane proteins such as the dopamine transporter SLC6A3, leading to the modulation of dopamine neurotransmission. In the endoplasmic reticulum, plays a role in the quality control of protein folding by increasing clearance of misfolded proteins such as SGCE variants or holding them in an intermediate state for proper refolding. May have a redundant function with TOR1B in non-neural tissues.

Gen-ID: 1861

UniProt: O14656

Pathways: SARS-CoV-2 Protein Interaktom