TOR1A Antikörper (AA 88-125)

Produktnummer ABIN7172305

Produktdetails anti-TOR1A Antikörper

Target: TOR1A (Torsin Family 1, Member A (Torsin A) (TOR1A))

Bindungsspezifität: AA 88-125

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TOR1A Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Torsin-1A protein (88-125AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu TOR1A

Target: TOR1A (Torsin Family 1, Member A (Torsin A) (TOR1A))

Andere Bezeichnung: TOR1A (TOR1A Produkte)

Synonyme: Dyt1 antikoerper, DQ2 antikoerper, DYT1 antikoerper, torsinA antikoerper, torsin family 1, member A antikoerper, torsin family 1 member A antikoerper, torsin family 1, member A (torsin A) antikoerper, Tor1a antikoerper, TOR1A antikoerper

Hintergrund:

Background: Protein with chaperone functions important for the control of protein folding, processing, stability and localization as well as for the reduction of misfolded protein aggregates. Involved in the regulation of synaptic vesicle recycling, controls STON2 protein stability in collaboration with the COP9 signalosome complex (CSN). In the nucleus, may link the cytoskeleton with the nuclear envelope, this mechanism seems to be crucial for the control of nuclear polarity, cell movement and, specifically in neurons, nuclear envelope integrity. Participates in the cellular trafficking and may regulate the subcellular location of multipass membrane proteins such as the dopamine transporter SLC6A3, leading to the modulation of dopamine neurotransmission. In the endoplasmic reticulum, plays a role in the quality control of protein folding by increasing clearance of misfolded proteins such as SGCE variants or holding them in an intermediate state for proper refolding. May have a redundant function with TOR1B in non-neural tissues.

Aliases: DQ2 antibody, Dystonia 1 antibody, Dystonia 1 protein antibody, Dystonia 1 torsion antibody, Dyt1 antibody, TOR1A antibody, TOR1A_HUMAN antibody, Torsin 1A antibody, Torsin A antibody, Torsin family 1 member A antibody, Torsin family 1, member A (torsin A) antibody, Torsin-1A antibody

UniProt: O14656

Pathways: SARS-CoV-2 Protein Interaktom