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ATG4D Antikörper

Dieses Anti-ATG4D-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von ATG4D in WB. Geeignet für Human.
Produktnummer ABIN4906368

Kurzübersicht für ATG4D Antikörper (ABIN4906368)

Target

Alle ATG4D Antikörper anzeigen
ATG4D (Autophagy related 4D Cysteine Peptidase (ATG4D))

Reaktivität

  • 46
  • 42
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
Human

Wirt

  • 68
  • 8
  • 1
Maus

Klonalität

  • 69
  • 8
Monoklonal

Konjugat

  • 29
  • 6
  • 5
  • 5
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser ATG4D Antikörper ist unkonjugiert

Applikation

  • 64
  • 29
  • 26
  • 26
  • 16
  • 11
  • 7
  • 6
  • 6
  • 2
  • 1
Western Blotting (WB)

Klon

2C1
  • Kreuzreaktivität

    Human

    Aufreinigung

    Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.

    Immunogen

    This ATG4D monoclonal antibody is generated from mouse immunized with ATG4D recombinant protein.

    Isotyp

    IgG1
  • Applikationshinweise

    WB 1:300-5000

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    0.5 μg/μL

    Buffer

    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C for 12 months.

    Haltbarkeit

    12 months
  • Target

    ATG4D (Autophagy related 4D Cysteine Peptidase (ATG4D))

    Andere Bezeichnung

    ATG4D

    Hintergrund

    Synonyms: APG4D, AUTL4, APG4-D, Cysteine protease ATG4D, AUT-like 4 cysteine endopeptidase, Autophagin-4, Autophagy-related cysteine endopeptidase 4, Autophagy-related protein 4 homolog D, ATG4D

    Background: Cysteine protease ATG4D: Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms. Cysteine protease ATG4D, mitochondrial: Plays a role as an autophagy regulator that links mitochondrial dysfunction with apoptosis. The mitochondrial import of ATG4D during cellular stress and differentiation may play important roles in the regulation of mitochondrial physiology, ROS, mitophagy and cell viability.

    Gen-ID

    84971

    UniProt

    Q86TL0

    Pathways

    Autophagie
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