ATG4C Antikörper

Produktnummer ABIN4906365

Dieses Anti-ATG4C-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von ATG4C in WB. Geeignet für Maus.

Kurzübersicht für ATG4C Antikörper (ABIN4906365)

Target: ATG4C (Autophagy related 4C Cysteine Peptidase (ATG4C))

Reaktivität: Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ATG4C Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: 7C2

Produktdetails anti-ATG4C Antikörper

Kreuzreaktivität: Maus

Aufreinigung: Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Immunogen: This ATG4C monoclonal antibody is generated from mouse immunized with ATG4C recombinant protein.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu ATG4C

Target: ATG4C (Autophagy related 4C Cysteine Peptidase (ATG4C))

Andere Bezeichnung: ATG4C

Hintergrund:

Synonyms: APG4C, AUTL1, AUTL3, APG4-C, Cysteine protease ATG4C, AUT-like 3 cysteine endopeptidase, Autophagin-3, Autophagy-related cysteine endopeptidase 3, Autophagy-related protein 4 homolog C, ATG4C

Background: Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Is not essential for autophagy development under normal conditions but is required for a proper autophagic response under stressful conditions such as prolonged starvation (By similarity). Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.

Gen-ID: 84938

UniProt: Q96DT6

Pathways: Autophagie