MLKL Antikörper (pSer358)

Produktnummer ABIN4901948

Der Maus Monoklonal anti-MLKL Antikörper wird verwendet zum Nachweis von MLKL in Proben von Human. Er wurde validiert für IHC (p).

Kurzübersicht für MLKL Antikörper (pSer358) (ABIN4901948)

Target: MLKL (Mixed Lineage Kinase Domain-Like (MLKL))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MLKL Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: 6F8

Produktdetails anti-MLKL Antikörper

Bindungsspezifität: pSer358

Verwendungszweck: MLKL is a protein encoded by the MLKL gene which is approximately 54,4 kDa. MLKL is localised to the cell membrane and cytoplasm. It is involved in the dimerization of procaspase-8, the TNF signalling pathway, apoptosis and autophagy. This protein falls under the protein kinase superfamily. It plays a critical role in tumour necrosis factor-induced necroptosis which is a programmed cell death process. It does this via interaction with the receptor-interacting protein 3 which is a key signalling molecule in necroptosis pathway. MLKL is expressed in the heart, intestine and lung. STJ97776 was developed from clone 6F8 and was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen MLKL. This primary antibody specifically binds to endogenous MLKL protein which only binds about S358 when S358 is phosphorylated.

Spezifität: Phospho-MLKL (S358) Mouse Monoclonal Antibody (6F8) detects endogenous levels of MLKL

Produktmerkmale: Mouse Monoclonal to phospho-MLKL (S358).

Aufreinigung: The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

Immunogen: synthetic peptide derived from phospho-MLKL (S358)

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: IHC 1:100-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze/thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C, and avoid repeat freeze-thaw cycles.

Details zu MLKL

Target: MLKL (Mixed Lineage Kinase Domain-Like (MLKL))

Andere Bezeichnung: MLKL

Gen-ID: 197259

UniProt: Q8NB16