Lamin A/C Antikörper
Kurzübersicht für Lamin A/C Antikörper (ABIN4901872)
Target
Alle Lamin A/C (LMNA) Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
Klon
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Verwendungszweck
- Mouse monoclonal to Lamin A.
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Spezifität
- This antibody detects endogenous levels of Lamin A and does not cross-react with related proteins.
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Produktmerkmale
- Mouse Monoclonal to Lamin A.
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Aufreinigung
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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Immunogen
- Purified recombinant human LMNA protein fragments expressed in E.coli.
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Isotyp
- IgG2a
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Applikationshinweise
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WB 1:500-2000
ELISA 1:10000-20000 -
Kommentare
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In the arteries, prelamin-A/C accumulation is not observed in young healthy vessels but is prevalent in medial vascular smooth muscle cells (VSMCs) from aged individuals and in atherosclerotic lesions, where it often colocalizes with senescent and degenerate VSMCs. Prelamin-A/C expression increases with age and disease. In normal aging, the accumulation of prelamin-A/C is caused in part by the down-regulation of ZMPSTE24/FACE1 in response to oxidative stress.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Konzentration
- 1 mg/mL
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Buffer
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Handhabung
- Avoid repeated freeze/thaw cycles.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- Store at -20°C, and avoid repeat freeze-thaw cycles.
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- Lamin A/C (LMNA)
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Andere Bezeichnung
- Lamin A
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Molekulargewicht
- 74kDa
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Gen-ID
- 4000
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UniProt
- P02545
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Pathways
- Apoptose, Caspase Kaskade in der Apoptose, ER-Nucleus Signaling, Protein targeting to Nucleus
Target
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