Lamin A/C Antikörper
Kurzübersicht für Lamin A/C Antikörper (ABIN4901871)
Target
Alle Lamin A/C (LMNA) Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
Klon
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Verwendungszweck
- Mouse monoclonal to Lamin A.
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Spezifität
- Lamin A Monoclonal Antibody detects endogenous levels of Lamin A protein.
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Produktmerkmale
- Mouse Monoclonal to Lamin A.
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Aufreinigung
- Affinity purification
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Immunogen
- Purified recombinant fragment of human Lamin A expressed in E. Coli.
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Isotyp
- IgG1
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Applikationshinweise
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WB 1:500-1:2000
IHC 1:200-1:1000
ELISA 1:10000 -
Kommentare
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In the arteries, prelamin-A/C accumulation is not observed in young healthy vessels but is prevalent in medial vascular smooth muscle cells (VSMCs) from aged individuals and in atherosclerotic lesions, where it often colocalizes with senescent and degenerate VSMCs. Prelamin-A/C expression increases with age and disease. In normal aging, the accumulation of prelamin-A/C is caused in part by the down-regulation of ZMPSTE24/FACE1 in response to oxidative stress.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Buffer
- Ascitic fluid containing 0.03 % sodium azide.
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Handhabung
- Avoid repeated freeze/thaw cycles.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- Store at -20°C, and avoid repeat freeze-thaw cycles.
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- Lamin A/C (LMNA)
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Andere Bezeichnung
- Lamin A
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Gen-ID
- 4000
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UniProt
- P02545
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Pathways
- Apoptose, Caspase Kaskade in der Apoptose, ER-Nucleus Signaling, Protein targeting to Nucleus
Target
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