Beclin 1 Antikörper (AA 110-190)

Produktnummer ABIN4901059

Dieses Maus Monoklonal-Antikörper erkennt spezifisch Beclin 1 in WB und IHC (p). Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für Beclin 1 Antikörper (AA 110-190) (ABIN4901059)

Target: Beclin 1 (BECN1) (Beclin 1, Autophagy Related (BECN1))

Reaktivität: Human, Maus, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Beclin 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: 5C2

Produktdetails anti-Beclin 1 Antikörper

Bindungsspezifität: AA 110-190

Verwendungszweck: Beclin-1 is a protein encoded by the ECN1 gene which is approximately 51,9 kDa. Beclin-1 is localised to the cytoplasm, Golgi apparatus and mitochondrion membrane. It is involved in the autophagy pathway, deubiquitination, metabolism of proteins, apelin signalling pathway and nanomaterial induced apoptosis. The beclin-1 protein is a component of the phosphatidylinositol-3-kinase (PI3K) complex which plays a role in multiple membrane trafficking pathways. PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. It also plays a role in multiple cellular processes, including tumorigenesis, neurodegeneration and apoptosis. Beclin-1 is ubiquitously expressed. Mutations in the ECN1 gene can result in cervical cancer, breast cancer and Wolfram syndrome. STJ97761 was affinity-purified from rabbit. This antibody detects endogenous beclin-1.

Spezifität: Beclin-1 Mouse Monoclonal Antibody (5C2) detects endogenous levels of BECN1

Produktmerkmale: Mouse Monoclonal to Beclin-1.

Aufreinigung: The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

Immunogen: synthetic peptide derived from Beclin-1

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: WB 1:1000-2000
IHC 1:100-200

Kommentare:

Ubiquitous.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze/thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C, and avoid repeat freeze-thaw cycles.

Details zu Beclin 1

Target: Beclin 1 (BECN1) (Beclin 1, Autophagy Related (BECN1))

Andere Bezeichnung: Beclin-1

Gen-ID: 8678

UniProt: Q14457

Pathways: Autophagie