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TLN2 Antikörper (Middle Region)

Dieses Anti-TLN2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von TLN2 in WB und IHC. Geeignet für Human, Maus und Ratte. Dieses Primary Antibody wurde in 1 Publikation zitiert.
Produktnummer ABIN4886745

Kurzübersicht für TLN2 Antikörper (Middle Region) (ABIN4886745)

Target

Alle TLN2 Antikörper anzeigen
TLN2 (Talin 2 (TLN2))

Reaktivität

Human, Maus, Ratte

Wirt

  • 15
  • 4
  • 1
Kaninchen

Klonalität

  • 14
  • 6
Polyklonal

Konjugat

  • 14
  • 2
  • 2
  • 2
Dieser TLN2 Antikörper ist unkonjugiert

Applikation

  • 16
  • 8
  • 8
  • 7
  • 5
  • 3
  • 3
Western Blotting (WB), Immunohistochemistry (IHC)
  • Bindungsspezifität

    • 6
    • 2
    • 1
    • 1
    • 1
    AA 1787-1822, Middle Region

    Verwendungszweck

    Anti-Talin 2/TLN2 Antibody Picoband®

    Sequenz

    NPKAQHTHDA ITEAAQLMKE AVDDIMVTLN EAASEV

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins

    Produktmerkmale

    Anti-Talin 2/TLN2 Antibody Picoband® (ABIN4886745). Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    A synthetic peptide corresponding to a sequence in the middle region of human Talin 2.

    Isotyp

    IgG
  • Applikationshinweise

    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Mouse, Rat
    Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
    1. "Entrez Gene: Talin 2". 2. Monkley SJ, Pritchard CA, Critchley DR (Sep 2001). "Analysis of the mammalian talin2 gene TLN2". Biochemical and Biophysical Research Communications 286 (5): 880-5. 3. Praekelt U, Kopp PM, Rehm K, Linder S, Bate N, Patel B, Debrand E, Manso AM, Ross RS, Conti F, Zhang MZ, Harris RC, Zent R, Critchley DR, Monkley SJ (Mar 2012). "New isoform-specific monoclonal antibodies reveal different sub-cellular localisations for talin1 and talin2". European Journal of Cell Biology 91 (3): 180-91.

    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Avoid repeated freezing and thawing.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Li, Li, Qi, Rychahou, Jafari, Huang: "The role of talin2 in breast cancer tumorigenesis and metastasis." in: Oncotarget, Vol. 8, Issue 63, pp. 106876-106887, (2017) (PubMed).

  • Target

    TLN2 (Talin 2 (TLN2))

    Andere Bezeichnung

    TLN2

    Hintergrund

    Synonyms: Talin-2,TLN2,KIAA0320,

    Tissue Specificity: Expressed in small intestine, and at much lower levels in kidney, skeletal muscle, and adipose tissue.

    Background: Talin 2 is a protein in humans that is encoded by the TLN2 gene. It belongs to the talin protein family. This gene encodes a protein related to talin 1, a cytoskeletal protein that plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. Talin-2 is expressed at high levels in cardiac muscle and functions to provide linkages between the extracellular matrix and actin cytoskeleton at costamere structures to transduce force laterally.

    Molekulargewicht

    271 kDa

    Gen-ID

    83660

    UniProt

    Q9Y4G6

    Pathways

    Cell-Cell Junction Organization, Maintenance of Protein Location
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