CRYAA Antikörper (AA 1-173)

Produktnummer ABIN4886549

Produktdetails anti-CRYAA Antikörper

Target: CRYAA (Crystallin, alpha A (CRYAA))

Bindungsspezifität: AA 1-173

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CRYAA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Verwendungszweck: Rabbit IgG polyclonal antibody for Alpha-crystallin A chain(CRYAA) detection. Tested with WB, IHC-P in Human,Mouse,Rat.

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Produktmerkmale: Rabbit IgG polyclonal antibody for Alpha-crystallin A chain(CRYAA) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
Gene Name: crystallin alpha A
Protein Name: Alpha-crystallin A chain

Aufreinigung: Immunogen affinity purified.

Immunogen: E. coli-derived human Alpha A Crystallin recombinant protein (Position: M1-S173). Human Alpha A Crystallin shares 94.8% amino acid (aa) sequence identity with both mouse and rat Alpha A Crystallin.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, Rat
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Mouse, Rat, Predicted Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Details zu CRYAA

Target: CRYAA (Crystallin, alpha A (CRYAA))

Andere Bezeichnung: CRYAA (CRYAA Produkte)

Synonyme: CRYA1 antikoerper, CTRCT9 antikoerper, HSPB4 antikoerper, AI323437 antikoerper, Acry-1 antikoerper, Crya-1 antikoerper, Crya1 antikoerper, DAcry-1 antikoerper, lop18 antikoerper, alpha-a-crystallin antikoerper, cryaa-A antikoerper, CRYAA antikoerper, wu:fc06h04 antikoerper, zgc:92036 antikoerper, HspB4 antikoerper, crystallin alpha A antikoerper, crystallin, alpha A antikoerper, alphaA-crystallin antikoerper, alpha-crystallin A chain-like antikoerper, crystallin alpha A S homeolog antikoerper, alpha-crystallin A chain antikoerper, CRYAA antikoerper, Cryaa antikoerper, CpipJ_CPIJ005646 antikoerper, cryaa antikoerper, LOC100384978 antikoerper, cryaa.S antikoerper, LOC458589 antikoerper, LOC102724652 antikoerper

Hintergrund: Alpha-crystallin A chain is a protein that in humans is encoded by the CRYAA gene. Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone, instead they hold them in large soluble aggregates. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alpha-A and alpha-B gene products are differentially expressed, alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Defects in this gene cause autosomal dominant congenital cataract (ADCC).

Synonyms: Acry 1 | CRYA 1 | CRYA1 | CRYAA | Crystallin alpha 1 | Crystallin alpha A | HSPB 4 | HspB4 | P02489

Gen-ID: 1409

UniProt: P02489

Pathways: M Phase