Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

ADAR Antikörper (AA 128-346)

ADAR Reaktivität: Human WB, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN4886426
  • Target Alle ADAR Antikörper anzeigen
    ADAR (Adenosine Deaminase, RNA-Specific (ADAR))
    Bindungsspezifität
    • 14
    • 14
    • 6
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 128-346
    Reaktivität
    • 79
    • 27
    • 22
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 75
    • 5
    • 1
    Kaninchen
    Klonalität
    • 67
    • 14
    Polyklonal
    Konjugat
    • 33
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser ADAR Antikörper ist unkonjugiert
    Applikation
    • 52
    • 25
    • 25
    • 20
    • 16
    • 10
    • 9
    • 7
    • 6
    • 5
    • 3
    • 3
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Verwendungszweck
    Anti-ADAR1 Antibody Picoband®
    Kreuzreaktivität (Details)
    No cross-reactivity with other proteins
    Produktmerkmale
    Anti-ADAR1 Antibody Picoband® (ABIN4886426). Tested in IF, IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
    Aufreinigung
    Immunogen affinity purified.
    Immunogen
    E.coli-derived human ADAR1 recombinant protein (Position: S128-Q346). Human ADAR1 shares 90.2% and 50.7% amino acid (aa) sequence identity with mouse and rat ADAR1, respectively.
    Isotyp
    IgG
    Top Product
    Discover our top product ADAR Primärantikörper
  • Applikationshinweise
    Western blot, 0.1-0.5 μg/mL, Human
    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human
    Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
    1. "Entrez Gene: ADAR Adenosine Deaminase Acting on RNA". 2. Kim U, Wang Y, Sanford T, Zeng Y, Nishikura K (November 1994). "Molecular cloning of cDNA for double-stranded RNA adenosine deaminase, a candidate enzyme for nuclear RNA editing". Proceedings of the National Academy of Sciences of the United States of America 91 (24): 11457-61.
    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Konzentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Target
    ADAR (Adenosine Deaminase, RNA-Specific (ADAR))
    Andere Bezeichnung
    ADAR (ADAR Produkte)
    Hintergrund

    Synonyms: Double-stranded RNA-specific adenosine deaminase,DRADA,3.5.4.37,136 kDa double-stranded RNA-binding protein,p136,Interferon-inducible protein 4,IFI-4,K88DSRBP,ADAR,ADAR1, DSRAD, G1P1, IFI4,

    Tissue Specificity: Ubiquitously expressed, highest levels were found in brain and lung. Isoform 5 is expressed at higher levels in astrocytomas as compared to normal brain tissue and expression increases strikingly with the severity of the tumor, being higher in the most aggressive tumors. .

    Background: Double-stranded RNA-specific adenosine deaminase, also known as ADAR1, is an enzyme that in humans is encoded by the ADAR gene. It is mapped to 1q21.3. This gene encodes the enzyme responsible for RNA editing by site-specific deamination of adenosines. This enzyme destabilizes double-stranded RNA through conversion of adenosine to inosine. Mutations in this gene have been associated with dyschromatosis symmetrica hereditaria. Alternative splicing results in multiple transcript variants.

    Molekulargewicht
    110 kDa, 150 kDa
    Gen-ID
    103
    UniProt
    P55265
    Pathways
    Protein targeting to Nucleus
Sie sind hier:
Chat with us!