EPH Receptor A2 Antikörper

Produktnummer ABIN488132

Der Maus Monoklonal Anti-EPH Receptor A2-Antikörper wurde für FACS, IF und EIA validiert. Er ist geeignet, EPH Receptor A2 in Proben von Human zu detektieren.

Kurzübersicht für EPH Receptor A2 Antikörper (ABIN488132)

Target: EPH Receptor A2 (EPHA2)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser EPH Receptor A2 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Klon: GM5H5

Produktdetails anti-EPH Receptor A2 Antikörper

Spezifität: Recognizes EphA2 receptor tyrosine kinase (EphA2).

Kreuzreaktivität (Details): Species reactivity (tested):Human.

Aufreinigung: Affinity Chromatography on Protein G.

Immunogen: Genetic immunisation with cDNA encoding Human EphA2 Remarks: Selection: Based on recognition of the complete native protein expressed on transfected mammalian cells

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: cELISA: 1/200-1/400. Flow Cytometry: 1.2 μg/10^6 cells. Immunofluorescence: 1 μg/10^6 cells.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 2.0 mg/mL

Buffer: Phosphate buffered saline, pH 7.2

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu EPH Receptor A2

Target: EPH Receptor A2 (EPHA2)

Andere Bezeichnung: EPHA2 / ECK

Hintergrund: EphA2 (Eph receptor tyrosine kinase A2) belongs to the Eph tyrosine receptor familiy, the largest receptor tyrosine kinase family of transmembrane proteins. It encodes a 130 kDA transmembrane protein which is primarily found in adult human epithelial cells (1). Eph receptors and their ephrin ligands are important mediators of cell-cell communication and play roles in embryonic patterning, neuronal targeting, and vascular development during normal embryogenesis (2,3). The Eph family of receptor tyrosine kinases is frequently overexpressed in a wide variety of cancers and tumor cell lines. In particular, EphA2 is overexpressed in prostate, lung and colon cancers and 40 % of breast cancers and it represent an attractive potential target for drug design (3,4).Synonyms: Eph receptor A2, Ephrin type-A receptor 2, Epithelial cell kinase, Tyrosine-protein kinase receptor ECK

Gen-ID: 1969

NCBI Accession: NP_004422

UniProt: P29317

Pathways: RTK Signalweg