Kurzübersicht für Tacrolimus (FK506) Antikörper (ABIN472100)
Target
Tacrolimus (FK506)
Wirt
Maus
Klonalität
Monoklonal
Konjugat
Unkonjugiert
Applikation
ELISA
Klon
FK1
Spezifität
Detects FK-506, a macrolide with similar but more potent immunosuppressant activity than cyclosporine. It is a 23-membered lactone produced by the bacteria Streptomyces tsukubaensis. FK-506 inhibits signal transduction and interleukin-2 transcription in CD4+ T helper lymphocytes, and is mainly used after allogeneic organ transplantation to reduce organ rejection. Side effects of FK-506 treatment include nephrotoxicity, neurotoxicity, diabetes mellitus and hypertension.