PKD2 Antikörper (Internal Region)

Produktnummer ABIN453986

Produktdetails anti-PKD2 Antikörper

Target: PKD2 (Polycystic Kidney Disease 2 (Autosomal Dominant) (PKD2))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte, Rind (Kuh)

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser PKD2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Spezifität: This antibody reacts to Polycystin 2 (PKD2).

Kreuzreaktivität (Details): Species reactivity (expected):Mouse, Rat, Bovine.
Species reactivity (tested):Human.

Aufreinigung: Affinity chromatography

Immunogen: Peptide with sequence C-ERAKLKRREVLGR, from the internal region of the protein sequence

Anwendungsinformationen

Applikationshinweise: Peptide ELISA: 1/2000. Western blot: 1 - 3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Details zu PKD2

Target: PKD2 (Polycystic Kidney Disease 2 (Autosomal Dominant) (PKD2))

Andere Bezeichnung: PKD2 (PKD2 Produkte)

Synonyme: APKD2 antikoerper, PC2 antikoerper, PKD4 antikoerper, Pc-2 antikoerper, TRPP2 antikoerper, C030034P18Rik antikoerper, RGD1559992 antikoerper, pkd2 antikoerper, trpp2 antikoerper, Cup antikoerper, PKD2L1 antikoerper, polycystin 2, transient receptor potential cation channel antikoerper, polycystic kidney disease 2 antikoerper, Polycystin-2 antikoerper, polycystin 2, transient receptor potential cation channel L homeolog antikoerper, PKD2 antikoerper, Pkd2 antikoerper, pkd-2 antikoerper, pkd2.L antikoerper, pkd2 antikoerper

Hintergrund: Mutations in the polycystin 2 gene are thought to be involved in autosomal dominant polycystic kidney disease, a condition characterised by renal cyst formation. Polycystin 2 has multiple membrane spanning domains with C and N terminal cytoplasmic domains, and has been found to be localised to the plasma membrane, ER and Golgi in various cell types and in cilia. It is thought to be involved in calcium signaling and transport and has been implicated in the development and morphology of renal tubules. It has been found to be regulated by EGF signalling. Interaction with polycystin 1 via the C terminus of both proteins is thought to be important for its function.Synonyms: Autosomal dominant polycystic kidney disease type II protein, Polycystic kidney disease 2 protein, Polycystin-2, Polycystwin, R48321

Gen-ID: 5311

NCBI Accession: NP_000288

UniProt: Q13563

Pathways: cAMP Metabolic Process, Maintenance of Protein Location, Negative Regulation of Transporter Activity