Kallikrein 6 Antikörper (C-Term)

Produktnummer ABIN453970

Dieser Ziege Polyklonal Antikörper detektiert spezifisch Kallikrein 6 in WB und EIA. Es zeigt Reaktivität gegenüber Proben von Maus, Ratte und Rind (Kuh).

Kurzübersicht für Kallikrein 6 Antikörper (C-Term) (ABIN453970)

Target: Kallikrein 6 (KLK6)

Reaktivität: Maus, Ratte, Rind (Kuh)

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser Kallikrein 6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-Kallikrein 6 Antikörper

Bindungsspezifität: C-Term

Sequenz: KEKPGVYTDV CTHIR

Kreuzreaktivität (Details): Species reactivity (expected):Rat and Cow.
Species reactivity (tested):Mouse.

Aufreinigung: Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide

Immunogen: Peptide from the C-Terminus of Mouse Kallikrein-6 according to NP_035307.1.

Anwendungsinformationen

Applikationshinweise: Peptide ELISA: Kallikrein-6 Antibody Detection limit dilution 1/16000. Western blot: 1-3 μg/mL. Approx 22 kDa band observed in Mouse Liver lysates (calculatedMW of 27.2 kDa according to NP_035307.1). An additional band of unknown identity wasalso consistently observed at 42 kDa. Both bands were successfully blocked by incubationwith the immunising peptide.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Details zu Kallikrein 6

Target: Kallikrein 6 (KLK6)

Andere Bezeichnung: KLK6 / Kallikrein-6

Hintergrund: Tissue kallikreins are a family of extracellular serine proteases consisting of 15 members (1, 2). The genes of this family aligned in tandem on chromosome 19q13.4 represent the largest contiguous group of proteases within the human genome. Tissue kallikreins have attracted great interest as potential biomarkers for various cancers, including prostate, ovarian, breast, testicular, and lung (2, 3). Human Kallikrein 6 (hKLK6) is a member of tissue kallikrein family observed in breast and brain tissues, colon carcinoma cells, and oligodedrocytes (1 3). Known protein substrates of hKLK6 are myelin basic protein, the precursor of the Abeta amyloid peptide, and plasminogen. Its physiological functions may include the participation in demyelination processes as well as in the progression of inflammatory disease of the CNS. The level of hKLK6 is reduced in brain extracts of Alzheimer patients and increased in serum of patients with ovarian cancer.Synonyms: Neurosin, PRSS18, PRSS9, Protease M, SP59, Serine protease 18, Serine protease 9, Zyme

Gen-ID: 5653

NCBI Accession: NP_001012982

UniProt: Q92876

Pathways: Komplementsystem, Regulation of G-Protein Coupled Receptor Protein Signaling