BRISC and BRCA1 A Complex Member 1 (BABAM1) (Middle Region) Antikörper

Produktnummer ABIN453692

Der Kaninchen Polyklonal Anti--Antikörper wurde für WB, IHC (p) und EIA validiert. Er ist geeignet, in Proben von Human zu detektieren.

Kurzübersicht für BRISC and BRCA1 A Complex Member 1 (BABAM1) (Middle Region) Antikörper (ABIN453692)

Target: BRISC and BRCA1 A Complex Member 1 (BABAM1)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails

Bindungsspezifität: Middle Region

Spezifität: This antibody recognizes MERIT40/HSPC142 (Center).

Aufreinigung: Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: KLH conjugated synthetic peptide selected from the Center region of Human HSPC142

Anwendungsinformationen

Applikationshinweise: ELISA: 1/1,000. Western blotting: 1/50-1/100. Immunohistochemistry: 1/50-1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) Sodium Azide as preservative.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Antigendetails

Target: BRISC and BRCA1 A Complex Member 1 (BABAM1)

Andere Bezeichnung: MERIT40

Hintergrund: Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. In these 2 complexes, it is probably required to maintain the stability of BRE/BRCC45 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36. component.Synonyms: BRCA1-A complex subunit MERIT40, C19orf62, HSPC142, Mediator of RAP80 interactions and targeting subunit of 40 kDa, NBA1, New component of the BRCA1-A complex

Gen-ID: 29086

NCBI Accession: NP_001028721

UniProt: Q9NWV8

Pathways: Positive Regulation of Response to DNA Damage Stimulus