ADRA2B Antikörper (AA 349-378)

Produktnummer ABIN453503

Der Kaninchen Polyklonal Anti-ADRA2B-Antikörper wurde für WB, IF, FACS, IHC (p) und EIA validiert. Er ist geeignet, ADRA2B in Proben von Human zu detektieren.

Kurzübersicht für ADRA2B Antikörper (AA 349-378) (ABIN453503)

Target: ADRA2B (Adrenergic, alpha-2B-, Receptor (ADRA2B))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ADRA2B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-ADRA2B Antikörper

Bindungsspezifität: AA 349-378

Spezifität: This antibody recognizes Alpha-2B adrenergic receptor.

Aufreinigung: Affinity Chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 349~378 amino acids from the Center region of Human ADRA2B. Genename: ADRA2B

Anwendungsinformationen

Applikationshinweise: ELISA: 1/1,000. Western blotting: 1/100 - 1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) Sodium Azide as preservative

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu ADRA2B

Target: ADRA2B (Adrenergic, alpha-2B-, Receptor (ADRA2B))

Andere Bezeichnung: alpha-2B Adrenergic Receptor

Hintergrund: Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Alpha 2B adrenergic receptor subtype was observed to associate with eIF-2B, a guanine nucleotide exchange protein that functions in regulation of translation. A polymorphic variant of the alpha2B subtype, which lacks 3 glutamic acids from a glutamic acid repeat element, was identified to have decreased G protein-coupled receptor kinase-mediated phosphorylation and desensitization, this polymorphic form is also associated with reduced basal metabolic rate in obese subjects and may therefore contribute to the pathogenesis of obesity. Alpha 2B adrenergic receptor gene contains no introns in either its coding or untranslated sequences.Synonyms: ADRA2B, ADRA2L1, ADRA2RL1, Alpha-2B adrenoceptor, Alpha-2B adrenoreceptor

Gen-ID: 151

NCBI Accession: NP_000673

UniProt: P18089

Pathways: EGFR Signaling Pathway, cAMP Metabolic Process