Carboxypeptidase B2 (Plasma) (CPB2) (AA 126-156) Antikörper

Details zu Produkt Nr. ABIN452866, Anbieter: Anmelden zum Anzeigen
Antigen
  • CPU
  • PCPB
  • TAFI
  • 1110032P04Rik
  • 4930405E17Rik
  • AI255929
  • CPR
  • Cpu
  • pCPB
  • zgc:112493
  • carboxypeptidase B2
  • carboxypeptidase B2 (plasma)
  • CPB2
  • Cpb2
  • cpb2
Epitop
AA 126-156
11
5
5
5
5
5
4
4
3
3
3
3
2
2
2
2
2
1
1
1
1
1
Reaktivität
Human
165
46
27
2
1
1
1
1
Wirt
Kaninchen
96
84
16
Klonalität
Polyklonal
Konjugat
Unkonjugiert
12
11
9
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Applikation
Enzyme Immunoassay (EIA), Western Blotting (WB)
130
104
26
13
10
10
9
7
5
3
3
2
2
2
2
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen KLH conjugated synthetic peptide selected between 126~156 amino acids from the Center region of Human CPB2
Spezifität This antibody detects CPB2 (aa 126~156).
Kreuzreaktivität (Details) Species reactivity (tested):Human,
Reinigung Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Antigen
Andere Bezeichnung Carboxypeptidase B2 (CPB2 Antibody Abstract)
Hintergrund Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). CPB2 is activated by trypsin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for its gene and its promoter region.Synonyms: CPB2, CPU, Carboxypeptidase U, Plasma carboxypeptidase B, TAFI, Thrombin-activable fibrinolysis inhibitor, pCPB
Molekulargewicht 48412 Da
Gen-ID 1361
NCBI Accession NP_001863
UniProt Q96IY4
Pathways Regulation of Actin Filament Polymerization, Carbohydrate Homeostasis
Applikations-hinweise ELISA: 1/1,000. Western blot: 1/50-1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) Sodium Azide as preservative.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freezing and thawing.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Bilder des Herstellers
 image for anti-Carboxypeptidase B2 (Plasma) (CPB2) (AA 126-156) antibody (ABIN452866) anti-Carboxypeptidase B2 (Plasma) (CPB2) (AA 126-156) antibody
Allgemeine Veröffentlichungen Valnickova, Thogersen, Christensen, Chu, Pizzo, Enghild: "Activated human plasma carboxypeptidase B is retained in the blood by binding to alpha2-macroglobulin and pregnancy zone protein." in: The Journal of biological chemistry, Vol. 271, Issue 22, pp. 12937-43, 1996 (PubMed).

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