Carboxypeptidase B2 (Plasma) (CPB2) (AA 126-156) Antikörper

Details zu Produkt Nr. ABIN452866, Anbieter: Anmelden zum Anzeigen
Antigen
  • CPU
  • PCPB
  • TAFI
  • 1110032P04Rik
  • 4930405E17Rik
  • AI255929
  • CPR
  • Cpu
  • pCPB
  • zgc:112493
  • carboxypeptidase B2
  • carboxypeptidase B2 (plasma)
  • CPB2
  • Cpb2
  • cpb2
Epitop
AA 126-156
11
5
5
5
5
5
4
4
3
3
3
3
2
2
2
2
2
1
1
1
1
1
Reaktivität
Human
172
45
26
2
1
1
1
1
Wirt
Kaninchen
94
92
16
Klonalität
Polyklonal
Konjugat
Unkonjugiert
12
11
9
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Applikation
Enzyme Immunoassay (EIA), Western Blotting (WB)
133
112
25
13
10
10
9
7
5
3
3
2
2
2
2
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen KLH conjugated synthetic peptide selected between 126~156 amino acids from the Center region of Human CPB2
Spezifität This antibody detects CPB2 (aa 126~156).
Kreuzreaktivität (Details) Species reactivity (tested):Human,
Reinigung Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Antigen Carboxypeptidase B2 (Plasma) (CPB2)
Andere Bezeichnung Carboxypeptidase B2 (CPB2 Antibody Abstract)
Hintergrund Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). CPB2 is activated by trypsin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for its gene and its promoter region.Synonyms: CPB2, CPU, Carboxypeptidase U, Plasma carboxypeptidase B, TAFI, Thrombin-activable fibrinolysis inhibitor, pCPB
Molekulargewicht 48412 Da
Gen-ID 1361
NCBI Accession NP_001863
UniProt Q96IY4
Pathways Regulation of Actin Filament Polymerization, Carbohydrate Homeostasis
Applikations-hinweise ELISA: 1/1,000. Western blot: 1/50-1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) Sodium Azide as preservative.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freezing and thawing.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Bilder des Herstellers
 image for anti-Carboxypeptidase B2 (Plasma) (CPB2) (AA 126-156) antibody (ABIN452866) anti-Carboxypeptidase B2 (Plasma) (CPB2) (AA 126-156) antibody
Allgemeine Veröffentlichungen Valnickova, Thogersen, Christensen, Chu, Pizzo, Enghild: "Activated human plasma carboxypeptidase B is retained in the blood by binding to alpha2-macroglobulin and pregnancy zone protein." in: The Journal of biological chemistry, Vol. 271, Issue 22, pp. 12937-43, 1996 (PubMed).

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