B-Cell Linker Antikörper (Middle Region)

Produktnummer ABIN452784

Der Kaninchen Polyklonal anti-B-Cell Linker Antikörper (ABIN452784) detektiert spezifisch B-Cell Linker in WB und EIA. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für B-Cell Linker Antikörper (Middle Region) (ABIN452784)

Target: B-Cell Linker (BLNK)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser B-Cell Linker Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-B-Cell Linker Antikörper

Bindungsspezifität: Middle Region

Spezifität: BLNK antibody recognizes BLNK at Center.

Kreuzreaktivität (Details): Species reactivity (tested):Human.

Aufreinigung: Protein A column followed by Peptide Affinity Purification.

Immunogen: This BLNK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the Center region of human BLNK.

Anwendungsinformationen

Applikationshinweise: ELISA: 1/1,000. Western Blot: 1/100approx. 1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) Sodium Azide as preservative

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu B-Cell Linker

Target: B-Cell Linker (BLNK)

Andere Bezeichnung: B-Cell Linker Protein / BLNK

Hintergrund: BLNK (B cell linker protein) is an adaptor molecule that plays key role in B cell activation initiated by cross-linking the B cell receptor (BCR). This activation leads to an increase in the tyrosine phosphorylation of a number of proteins due to activation of nonreceptor protein tyrosine kinases (PTK) including Syk, which is responsible for the tyrosine phosphorylation of BLNK. BLNK is cytosolic protein identified as two phosphoproteins migrating at 68 and 70 kDa in SDS/PAGE (alternatively spliced forms of human BLNK). Mapping of the tyrosine residues in BLNK reveal three tyrosines that bind PLC-gamma2, and two tyrosines that bind the Tec family kinase Btk, the Vav nucleotide exchange factor and the adaptor Nck.Synonyms: B-cell adapter containing a SH2 domain protein, B-cell adapter containing a Src homology 2 domain protein, BASH, Cytoplasmic adapter protein, SLP-65, SLP65, Src homology 2 domain-containing leukocyte protein of 65 kDa

Gen-ID: 29760

NCBI Accession: NP_001107566

UniProt: Q8WV28

Pathways: BCR Signaling