FPR2
Reaktivität: Human
IHC, IHC (p)
Wirt: Kaninchen
Polyclonal
unconjugated
Applikationshinweise
ELISA. Western Blot (1/1000). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Rekonstitution
Restore with Double distillated water to adjust the final concentration to 1.0 mg/mL
Buffer
0.01 M PBS, pH 7.2 without preservatives
Konservierungsmittel
Without preservative
Lagerung
-20 °C
Informationen zur Lagerung
Store the antibody (in aliquots) at -20 °C. Avoid repeated freezing and thawing. Shelf life: One year from despatch.
Haltbarkeit
12 months
Target
FPR2
(Formyl Peptide Receptor 2 (FPR2))
Andere Bezeichnung
FPR2 / FPRL1
Hintergrund
FPRL1 is a low affinity receptor to N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4). FPRL1 has been reported in phagocytes, monocytes, neutrophils, differentiated myeloid cells from bone marrow, granulocyte HL-60 cells, and synovial fibroblasts. ESTs have been isolated from blood, leukocyte, lung, and placenta libraries.Synonyms: FMLP-R-I, FMLP-related receptor I, FPRH1, Formyl peptide receptor-like 1, LXA4R, Lipoxin A4 receptor, N-formyl peptide receptor 2, RFP