M-CSF/CSF1 Antikörper

Produktnummer ABIN452499

Dieses Anti-M-CSF/CSF1-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von M-CSF/CSF1 in EIA. Geeignet für Human.

Kurzübersicht für M-CSF/CSF1 Antikörper (ABIN452499)

Target: M-CSF/CSF1 (CSF1) (Colony Stimulating Factor 1 (Macrophage) (CSF1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser M-CSF/CSF1 Antikörper ist unkonjugiert

Applikation: Enzyme Immunoassay (EIA)

Klon: 116

Produktdetails anti-M-CSF/CSF1 Antikörper

Spezifität: This monoclonal antibody is specifically reactive to rhM-CSF. Does not cross react with BSA or other Human cytokines tested such as IL1 beta, IL-8, IL-16, EGF, G-CSFR, GM-CSF, MCP-1, MCP-3, TGF beta and TNF alpha.

Kreuzreaktivität (Details): Species reactivity (tested):Human.

Produktmerkmale: Synonyms: CSF-1, CSF1, MCSF, Macrophage colony-stimulating factor 1

Aufreinigung: Affinity Chromatography on Protein G.

Immunogen: Purified recombinant Human M-CSF (rhM-CSF).

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: ELISA.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: Restore with Double distillated water to adjust the final concentration to 1.00 mg/mL

Buffer: 0.01 M PBS, pH 7.2 without preservatives.

Konservierungsmittel: Without preservative

Lagerung: -20 °C

Informationen zur Lagerung: Store the antibody (in aliquots) at -20 °C. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu M-CSF/CSF1

Target: M-CSF/CSF1 (CSF1) (Colony Stimulating Factor 1 (Macrophage) (CSF1))

Andere Bezeichnung: Macrophage Colony Stimulating Factor (M-CSF)

Hintergrund: Four distinct colony-stimulating factors (CSFs) that promote survival, proliferation and differentiation of bone marrow precursor cells have been well characterized: granulocyte macrophage CSF (GMCSF), granulocyte CSF (GCSF), macrophage CSF (MCSF), and Interleukin-3 (IL-3, Multi CSF). Both GMCSF and IL-3 are multipotential growth factors, stimulating proliferation of progenitor cells from more than one hematopoietic lineage. In contrast, GCSF and MCSF are lineage restricted hematopoietic growth factors, stimulating final mitotic divisions and the terminal cellular maturation of the partially differentiated hematopoietic progenitors. Macrophage CSF, also known as CSF1, is produced by monocytes, fibroblasts and endothelial cells. It stimulates the formation of macrophage colonies, enhances antibody-dependent, cell-mediated cytotoxicity by monocytes and macrophages, and inhibits bone resorption by osetoclasts. Natural human MCSF is a dimeric glycoprotein of 70-90 kD molecular weight, existing in multiple glycosylation forms. It binds to a 165 kD glycoprotein of the receptor tyrosine kinase subclass III, a family that includes the receptors for platelet derived growth factor (PDGF) and stem cell factor (SCF).Synonyms: CSF-1, CSF1, MCSF, Macrophage colony-stimulating factor 1

Gen-ID: 1435

UniProt: P09603

Pathways: RTK Signalweg