TIMELESS Antikörper (N-Term)

Produktnummer ABIN410144

Der Kaninchen Polyklonal Anti-TIMELESS-Antikörper wurde für WB, ELISA und IHC validiert. Er ist geeignet, TIMELESS in Proben von Human zu detektieren.

Kurzübersicht für TIMELESS Antikörper (N-Term) (ABIN410144)

Target: TIMELESS (Timeless Homolog (TIMELESS))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TIMELESS Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-TIMELESS Antikörper

Bindungsspezifität: N-Term

Spezifität: Reacts with human 138 kDa protein

Kreuzreaktivität: Maus, Ratte (Rattus)

Kreuzreaktivität (Details): Cross reacts with proteins from mouse, rat and other species.

Aufreinigung: Antiserum

Immunogen: Synthetic peptide derived from Nter domain of human hTIM protein

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only :
- IHC : 1/50 to 1/200 - WB : 1/100 to 1/1 000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Must be reconstituted in distilled water.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Lyophilized powder stable for a minimum of 2 years at -20°C. Store reconstituted antibodies at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt.

Haltbarkeit: 24 months

Details zu TIMELESS

Target: TIMELESS (Timeless Homolog (TIMELESS))

Andere Bezeichnung: Protein Timeless Homolog (hTIM)

Hintergrund: Required for normal progression of S-phase. Involved in the circadian rhythm autoregulatory loop. Negatively regulates CLOCK-NPAS2/BMAL1-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus. Promotes TIPIN nuclear localiZation. Involved in cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. May also play an important role in epithelial cell morphogenesis and formation of branching tubules.

UniProt: Q9UNS1

Pathways: Protein targeting to Nucleus, Photoperiodism